Practice Information

Disclaimer: Practice guidelines provide licensees with general guidance to promote good practice. Law, rules and regulations, not guidelines, specify the requirements for practice and what may constitute professional misconduct.

Antibody Therapy (Intravenous or Subcutaneous Infusions)


An RN may administer antibody therapy (i.e., immunoglobulin therapy or monoclonal antibodies) pursuant to a valid patient specific order, under the following conditions:

  • The order defines the type, dose, route (intravenous or subcutaneous) and rate of administration of the antibody therapy, as well as monitoring requirements and premedication, if indicated.
  • A physician or other qualified practitioner must be immediately available to respond to an adverse reaction during the administration of the antibody therapy.
  • An emergency code cart and other emergency equipment and supplies must be immediately available during the infusion of the antibody therapy.
  • Health facility protocols permit the RN to administer ordered antibody therapy, monitor the patient and handle complications.
  • The RN has completed appropriate training covering the care of patients receiving antibody therapy and successfully demonstrates clinical competence in providing intravenous antibody therapy care at least annually.
  • Informed consent has been obtained, pursuant to health facility policy.

LPNs may NOT administer antibody therapy (monoclonal antibodies or immunoglobulins) intravenously, by subcutaneous infusion or subcutaneous intermittent infusion as this requires ongoing nursing assessment while the patient receives the infusion. An LPN may administer a single subcutaneous injection of antibodies, pursuant to an order, provided that an RN or other qualified practitioner is immediately available to perform any required assessment or respond to an adverse reaction.

Last Updated: April 15, 2021