Clinical Laboratory Technology

Application documents received prior to the date noted below are currently in the initial stage of processing. The timeframe for the review and evaluation of these materials varies. Applications with education from outside the U.S. usually require a lengthier review process. All applicants should allow an additional 6-8 weeks for review after this date before submitting a Contact Us Form to request a status update, as contacting us earlier will delay processing. We cannot provide the status of a licensure application by phone. We thank you for your patience and cooperation.

Profession Currently Initiating the Process for Items Received
Clinical Laboratory Technologists 11/23/2022
Clinical Laboratory Technicians 11/21/2022
Cytotechnologists 11/21/2022
Histological Technicians 11/22/2022

Advisory Notice: For the latest information on COVID-19 issues impacting the licensed professions, including professional exam updates, please visit OP’s COVID-19 website.

Advisory Notice

Additional Courses that may be Acceptable toward Meeting Certain Subject Area Requirements in the Clinical Laboratory Technology, Cytotechnology, and Clinical Laboratory Technician Professions

Part 52 of the Commissioner’s Regulations requires that the professional education for clinical laboratory professionals includes coursework in specific subject areas or their equivalent as determined by the Department. The Department has undertaken a recent review of the essential content within those specific subject areas and determined that additional courses may be considered equivalent if, upon review, it is determined by the Department that they sufficiently cover the required topics/contents as outlined in the chart below.

Instructions for Applicants:

If you have previously submitted an application and were found deficient in any of these areas, and you have completed the course(s) that may be acceptable, as identified in the chart below and wish to have your application re-evaluated, please request that your school submits the relevant course syllabus for each course (from the time of your attendance) to

Note: If you withdrew your application and obtained a refund, you are required to submit a new Form 1 and application fee. You may also be required to submit official transcripts and other documents.

Please be advised that requests will be reviewed in the order in which they are received.
Subject Areas Topics that Must be Covered Additional Courses that may be Acceptable
Molecular Biology and Diagnostics with Lab [52.38 (b)(8)]
  1. The structure and function of nucleic acids
  2. Replication, transcription and translation
  3. Introduction to polymerase chain reaction (PCR)
Cell Biology with Lab OR
Genetics with Lab OR
Biochemistry with Lab

Note: Acceptable ONLY if you also completed a course in analytic chemistry, or its equivalent
Physiology with Anatomy Content with Lab [52.38(b)(4) and 52.40(b)(3)]

Anatomy and Physiology [52.39(b)(2)]
Systems that must be covered: Circulatory (cardiovascular); digestive (excretory); endocrine; integumentary/exocrine; lymphatic (immune); muscular; nervous; urinary (renal); reproductive; respiratory; skeletal Human Biology with Lab
Biochemistry with Lab [52.38(b)(2)]
  1. Structure and function of carbohydrates, lipids, proteins, enzymes
  2. Cellular respiration
  3. Cellular metabolism
Biotechnology with Lab

Note: Clinical Chemistry is a required course outlined in regulation and while it may contain similar topics as a Biochemistry course, it cannot be used to meet the Biochemistry requirement.

Advisory Notice:

NYSED has eliminated the September 1, 2001 cutoff date for the licensing examinations in all four (4) laboratory professions: Clinical Laboratory Technologist; Certified Clinical Laboratory Technician; Cytotechnologist; and Certified Histological Technician. If you passed the ASCP examination, you are advised to contact ASCP to request that your examination score is transferred to NYSED. In addition, NYSED accepts the American Society for Clinical Pathology Board of Certification's International (ASCPi) examinations to meet the New York State examination requirement for licensure in each of the four (4) clinical laboratory professions according to the chart below. This notice applies to the Department's acceptance of these examinations. The Department still does not accept national or international certification for licensure in New York State. Applicants must still meet the professional education requirements as outlined on our website.

Clinical Laboratory Technologist Exam Requirements Date Accepted for Licensure
ASCP (MLS) No cutoff date NEW
ASCPi (MLS) January 1, 2015
Clinical Laboratory Technician Exam Requirements Date Accepted for Licensure
ASCP (MLT) No cutoff date NEW
ASCPi (MLT) October 1, 2014  
Cytotechnologist Exam Requirements Date Accepted for Licensure
ASCP (CT) No cutoff date, NEW
ASCPi (CT) (see additional information on the license requirements page.) April 1, 2015
Histological Technician Exam Requirements Date Accepted for Licensure
ASCP (HT) No cutoff date NEW
ASCPi (HT) April 1, 2015  
ASCP (HTL) No cutoff date NEW
ASCPi (HTL) October 1, 2014  

Federal Initiatives Related to Nurses and Clinical Laboratory Practice

Two federal initiatives (described below) have caused concern among some professionals in New York.
  • The federal Department of Veterans Affairs (VA) proposed a regulation to allow Advanced Practice Registered Nurses to supervise and perform laboratory tests in VA laboratory facilities. New York State does not regulate VA laboratory facilities or VA laboratory staff.
  • The Centers for Medicare & Medicaid Services (CMS) indicated that that Clinical Laboratory Improvement Act (CLIA) allows RNs with BSNs to perform moderate and high complexity laboratory tests and RNs with ADNs to perform moderate complexity tests. CLIA does not apply to New York State Clinical Laboratories or to any staff who work for these laboratories. Federal Law specifically allows New York State to regulate New York State Clinical Laboratories in accordance with New York State Law.
Please see Questions & Answers related to Practice of Clinical Laboratory Technology Professionals for an Advisory related to these initiatives.

Clinical Laboratory Technology Practitioners are clinical laboratory technologists, cytotechnologists, certified clinical laboratory technicians and certified histological technicians who work in licensed clinical laboratories and practice clinical laboratory technology.

Clinical Laboratory Technology Practitioners are an essential part of the team of health care professionals. They perform tests and procedures on all bodily fluids and tissue that are critical to the diagnostic process in determining health and disease. They also have a critical role in determining the nature of substances that are used by bioterrorists.

At least 70% of all diagnoses rely on testing done by clinical laboratory technology professionals. 

Read more about this profession.

Last Updated: November 28, 2022